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  • NCT04975997

Recruiting

Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) - CC-220-MM-002

Updated: 16 November, 2024   |   ClinicalTrials.gov

Celgene Corporation, a wholly owned subsidiary of Bristol-Myers Squibb Company

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CONSIDERING THIS TRIAL?
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Use the Study Participant's Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.
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Trial Details

  • Phase 3

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 245

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Active Comparator: Daratumumab in combination with dexamethasone and bortezomib
Drug: Dexamethasone, Daratumumab, Bortezomib
Experimental: Daratumumab in combination with Iberdomide and dexamethasone - Dose 1
Drug: Dexamethasone, Daratumumab, Iberdomide
Experimental: Daratumumab in combination with Iberdomide and dexamethasone - Dose 2
Drug: Dexamethasone, Daratumumab, Iberdomide
Experimental: Daratumumab in combination with Iberdomide and dexamethasone - Dose 3
Drug: Dexamethasone, Daratumumab, Iberdomide

Key Eligibility Criteria

Inclusion Criteria - Documented diagnosis of multiple myeloma (MM) and measurable disease. - Received 1 to 2 prior lines of anti-myeloma therapy. - Must have documented disease progression during or after their last anti-myeloma regimen. - Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1 or 2. Exclusion Criteria - Any condition that confounds the ability to interpret data from the study. - Has plasma cell leukemia, Waldenstrom's macroglobulinemia or POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes), or clinically significant amyloidosis. - Known central nervous system involvement with MM. - Prior therapy with iberdomide. - Other protocol-defined Inclusion/Exclusion criteria apply.

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Side Effects (Adverse Events) and other reportable events are defined here
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