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  • NCT06476808

Recruiting

A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors. - CA231-0000

Updated: 28 May, 2025   |   ClinicalTrials.gov

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CONSIDERING THIS TRIAL?
Print this page and the trial guide to help you talk with your doctor.
Use the Study Participant's Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.
Print this page CA231-0000
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SELECT LANGUAGE

Trial Details

  • Phase 1

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 6

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Arm 1: Dose Escalation
Drug: BMS-986463
Experimental: Arm 2: Dose Expansion
Drug: BMS-986463

Key Eligibility Criteria

Inclusion Criteria - Participants must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1. - Participants must have at least 1 lesion accessible for biopsy in addition to the target lesion, from which a fresh pre treatment biopsy must be obtained. - Participants must have an unresectable/metastatic carcinoma. Exclusion Criteria - Participants must not have Leptomeningeal metastases. - Participants must not have concurrent malignancy (present during screening) requiring treatment or history of prior malignancy active within 2 years prior to treatment. - Participants must not have had any prior radiation therapy within 2 weeks prior to start of study treatment. - Other protocol-defined Inclusion/Exclusion criteria apply.

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We recommend that you also contact BMS to report side effects.
Side effects and other reportable events are defined here
Report side effects or product quality complaints: Medical Information

466-DK-2200001