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  • NCT04975997

Recruiting

Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) - CC-220-MM-002

Updated: 16 November, 2024   |   ClinicalTrials.gov

Celgene Corporation, a wholly owned subsidiary of Bristol-Myers Squibb Company

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CONSIDERING THIS TRIAL?
Print this page and the trial guide to help you talk with your doctor.
Use the Study Participant's Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.
Print this page CC-220-MM-002
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Trial Details

  • Phase 3

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 245

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Active Comparator: Daratumumab in combination with dexamethasone and bortezomib
Drug: Dexamethasone, Daratumumab, Bortezomib
Experimental: Daratumumab in combination with Iberdomide and dexamethasone - Dose 1
Drug: Dexamethasone, Daratumumab, Iberdomide
Experimental: Daratumumab in combination with Iberdomide and dexamethasone - Dose 2
Drug: Dexamethasone, Daratumumab, Iberdomide
Experimental: Daratumumab in combination with Iberdomide and dexamethasone - Dose 3
Drug: Dexamethasone, Daratumumab, Iberdomide

Key Eligibility Criteria

Inclusion Criteria - Documented diagnosis of multiple myeloma (MM) and measurable disease. - Received 1 to 2 prior lines of anti-myeloma therapy. - Must have documented disease progression during or after their last anti-myeloma regimen. - Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1 or 2. Exclusion Criteria - Any condition that confounds the ability to interpret data from the study. - Has plasma cell leukemia, Waldenstrom's macroglobulinemia or POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes), or clinically significant amyloidosis. - Known central nervous system involvement with MM. - Prior therapy with iberdomide. - Other protocol-defined Inclusion/Exclusion criteria apply.

If you want to report a side effect, you can report directly to the Danish Medicines Agency via the website www.meldenbivirkning.dk
We recommend that you also contact BMS to report side effects.
Side effects and other reportable events are defined here
Report side effects or product quality complaints: Medical Information

466-DK-2200001